Intacef Tazo injection is a brand or premium veterinary medicine, its formulations helps to treat severe infection in dogs and cats. The brand name is Intas that launch this injection. Intas is reputed brand. A potent cephalosporin antibiotic that effect wide range of bacterial cell wall synthesis. Tazobactam includes synergistically effect with Ceftriaxone enhancing its efficacy by inhibiting bacterial resistance mechanisms.
These ingredients are effectively treat various bacterial infection i.e. Broad – Spectrum Antibiotic. This antibiotic specially formulated for dogs and cats. This antibiotic used to treat respiratory tract infections, urinary tract infections, Skin or soft tissue infection, bone and joint infections and certain sexually transmitted disease in pets.
Composition : Intacef Tazo 562.50 mg
Each vial contains :
Ceftriaxone Sodium IP ( sterile ) eq. to Anhydrous Ceftriaxone………..500 mg
Tazobactam Sodium IP ( sterile ) eq. to Tazobactam………………………………62.5 mg
Description : Intacef Tazo ( Ceftriaxone & Tazobactam ) – Intacef Tazo
Intacef tazo is a combination of synergistic Ceftriaxone Sodium and Tazobactam Sodium available as a dry powder for reconstitution. Ceftriaxone Sodium is a third generation , semi-synthetic , broad spectrum, bactericidal cephalosporin with molecular weight of 661.61. It is a white to yellowish orange crystalline powder, which is rapidly soluble in water and sparingly soluble in alcohol. Tazobactam sodium is the derivative of triazoymethyl penicillanic acid sulfone. It is a white off – white dry powder soluble in aqueous solvent.
Pharmacology of Intacef Tazo 562.50 mg – Intacef Tazo
Firstly we must have to understand about the mechanism of action of Intacef tazo 562.50 mg. Ceftriaxone found in this injection is a beta – lactam antibiotic that produces its bacterial effect by inhibition of the cell wall synthesis. Ceftriaxone has high degree of stability in the presence of the beta – lactamases both penicillinase and cephalosporinases of the gram negative and gram positive bacteria. Ceftriaxone is a type of broad spectrum anti-biotic.
Tazobactam :
Tazobactam is semi – synthetic beta-lactamase inhibitor. Tazobactam exhibits a moderate antibacterial activity that is relative to its affinity for the penicillin binding proteins of the various bacterial strains. It is a potent, highly specific irreversible inhibitor of beta – lactamases and extended spectrum beta – lactamase produced by the gram negative and gram positive aerobes and aerobes. Tazobactams binds itself with these enzymes and blocks their destructive hydrolytic activity.
Addition of Tazobactams with Ceftriaxone provides the following additional benefits :
Enhanced efficacy against beta – lactamases and extended spectrum beta-lactamases producing organisms.
Synergistic activity ( Reduction in minimum inhibitory concentration for the combination versus those of each component ).
Pharmacokinetics of Intacef Tazo
Ceftriaxone is widely distributed through the most body fluids and the tissues including kidney, lungs, bone, soft tissues, biliary tracts and extravascular spaces, pleural fluids, peritoneal fluids, synovial fluids and pericardial fluids. Ceftriaxone has excellent antibacterial activity against a wide range of gram negative and gram positive organisms. Ceftriaxone because of its extensive protein binding and half life of 8 hours offers once daily dose potential. Ceftriaxone is deacetylated primarily in the liver and kidney, the renal elimination is by renal tubular and glomerular filtration. The combination of Ceftriaxone and Tazobactam offers a broad spectrum bactericidal activity along with inhibition of beta lactamases and extended spectrum beta – lactamase which are a major threat to clinical therapeutics today.
Gram negative aerobes are :
Actinobacillus spp., Borrelia burgdorferi, Citrobacter spp., Enterobacter aerogenes, Enterobacter cloacae, Escherichia coli, Hemophilus spp., klebsiella pneumoniae, klebsiella oxytoca, Moraxella spp., Neisseria spp., Pasterurella haemolytica, Pasterurella multocida, Pasterurella multocida, Proteus mirabilis, Proteusvulgaris, Pseudomonas aeruginosa, Salmonella spp., Serratia marcescens, Shigella spp.
Gram positive aerobes are :
Staphylococcus aureus, Staphylococcus epidermis, Staphylococcus hemolyticus, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus viridans, Streptococcus agalactiae, Streptococcus epidermis, Bacillus spp.
Anaerobes :
Clostridium spp., Bacteroids fragilis and Fusobacterium spp.
Indications :
- Respiratory infections e.g. Pneumonia/Bronchopneumonia.
- Hemorrhagic septicemia.
- Mastitis.
- Urogenital tract infections.
- Bone and joint infections.
- Meningitis.
- Septicemia.
- Gastro-Intestinal infections.
- Pre – Operative care.
Dosage and Administration :
Intacef tazo is to be administered by the intramuscular / intravenous route after reconstitution at the dose rate of 5 – 10 mg/k.g.b.wt. in livestock, 15-25 mg/kg body weight in equines.
Intacef Tazo is available along with the sterile water for injections IP, disposable syringes and needle.
Safety ; This injection is safe for administered in young and pregnant animals. This injection does not produce any impairment of fertility, embryo toxicity and teratogenicity.
This injection is a type of broad spectrum antibiotic that effect on both gram negative and gram positive bacteria.
Side Effects ; Intacef Tazo
While this is generally safe but used to be cautiously in pets with liver and kidney issues. Few side effect include diarrhea and rash at injection site. If your pet is on to be with Intacef tazo then you must have to monitored on daily basis. If any side effects shown then contact with your veterinarian.
Question : Is Intacef an antibiotic ?
Ans. Yes, it is an antibiotic medicine containing ceftriaxone, belonging to the cephalosporin class of medicine. This injection will be used under the supervision of doctor or nurse. Dosage will recommended by your doctor must follow this.
Question : What is the use of Intacef tazo injection in veterinary ?
Ans. Intacef Tazo Veterinary injection is commonly used to treat a wide range of bacterial infections in animals, including respiratory tract infection, skin and soft tissue infections, urinary tract infections, and septicemia.